Methylsulfonylmethane: characteristics, methods of use and possible contraindications

Metilsulfonilmetano: le caratteristiche, modalità d’uso e le possibili controindicazioni

In short.

In detail we will talk about

The uses of methylsulfonylmethane for food supplementation with characteristics and methods of use. Plus, intuitive graphics on side effects and contraindications

There are many secrets that allow methylsulfonylmethane to be considered as a decisive element for food supplementation. These are contained in its formula which allows to identify fundamental elements such as sulfur . It is important in terms of food because it is contained in many foods and represents a decisive molecule when it is necessary to integrate proteins in the diet.

In combination with glucosamine and chondroitin , methylsulfonylmethane represents a sort of “closure of the circle” as regards food supplementation. We collect all its qualities, methods of use and main contraindications and side effects in this in-depth study.

Inside there will be room for a deeper understanding of the characteristics and applications of methylsulfonylmethane. Together with these also important notes on the dosage and a simple graphic on the contraindications and on what are the main side effects.

Methylsulfonylmethane MSM: what is it and what is it used for?

In the title of this paragraph we have used the acronym MSM which stands for methyl-sulfonyl-methane. But, more specifically, what is meant by methylsulfonylmethane?

What is methyl-sulfonyl-methane?

This name identifies a molecule that can be easily found in nature and that can be used , if properly synthesized, in food supplements and nutraceuticals .

As pointed out in the introduction, within this molecule it is possible to trace sulfur in bond with two molecules of oxygen and two of methyl . Hence the definition of organosulfide, therefore containing sulfur in a condition of biocompatibility. This organic nature, therefore, is very useful to improve and speed up its absorption.

What is methylsulfonylmethane used for?

It is precisely sulfur that represents a fundamental element in the human diet, as it is present in high quantities in our body. Here, therefore, that the integration of this element, present in the MSM, becomes fundamental. How is sulfur present in our body?

One thing that not many people know is that sulfur is one of the most present elements in our body. In similar quantities, in our body, potassium is present, while in lower quantities both chlorine and sodium are present. It therefore represents an element in the “top 10” in the ranking of those most present in our body.

It goes without saying that the positive effects that certify its qualities are the most varied. In the next paragraph we will see what are the main properties attributed to this molecule.

What are the properties of methylsulfonylmethane?

When we talk about the positive effects of methyl-sulfonyl-methane we must refer to different areas of our body, precisely because of the presence in high quantities of sulfur in our body.

Where is methylsulfonylmethane MSM found in our bodies ? It is mainly proteins that store large amounts of MSM. In muscle proteins , for example, we find several elements that contain this molecule, including:

  • Cystine;
  • Taurine;
  • Cysteine;
  • Homocysteine;
  • Methionine.

We are talking about the main sulfur amino acids found within muscle proteins. But what are the real benefits of taking MSM? There are still many studies in progress that are trying to demonstrate some further positive uses of this molecule.

In some supplements, sulfur is used with great success when it comes to facilitating faster hair regrowth. Here, therefore, that the function of this element is expressed with great effectiveness in combination with other elements.

Methylsulfonylmethane, glucosamine and chondroitin

More and more often we hear about supplements and nutraceuticals capable of effectively combining the beneficial action of glucosamine, chondroitin and methylsulfonylmethane. In this regard, it is appropriate to refer the topic to further sources that can be found in our blog:

These three elements, in concert with other useful principles, are able to guarantee positive effects as regards:

  • Strengthening of cartilage tissue;
  • Cartilage lubrication and strengthening;
  • Joint lubrication in general;
  • Reduction of the symptoms of arthrosis due to aging;
  • Reduction of arthrosis symptoms for trauma suffered.

In short, a series of positive effects that are completed when the combination of molecules is truly integrated. This happens, for example, in those products that also include other principles. Let’s see what these principles are.

Methylsulfonylmethane supplements: when they are 100% effective

In combination with other molecules, methylsulfonylmethane is able to act in a more functional way. This happens in all those supplements that also include the use of:


It serves primarily to act as a stimulus for the production of cartilage . This means that the action of chondroitin directly allows the functioning of the tissues to be kept in balance . In practice, it helps to delay the degradation of cartilage.


An indispensable element to block the factors that lead to a faster degeneration of the tissues towards osteoarthritis. But not only that, with glucosamine it is possible to mitigate the condition of inflammation of the tissues .


In nature, collagen is quite simple to identify and its usefulness means that it is increasingly used in the making of functional supplements to help maintain tissue elasticity . The bioavailability of short-chain hydrolyzed collagen is further justified, in use, by the possibility of using this source which is also easy for our body to absorb .

Hyaluronic acid

The advantages that hyaluronic acid guarantees in its use are twofold. The first relates to the efficiency with which this collects water . This peculiarity allows to keep the cushioning action that this provides to the elastic fabrics balanced. This means that a good integration of hyaluronic acid in the diet allows you to fight all those symptoms that characterize the wear and tear of the cartilages .

Precisely these elements characterize a balanced functioning of the integrator. Together they are of great benefit to the health of these tissues. In the next section we will analyze the benefits of methylsulfonylmethane.

Methylsulfonylmethane: what are the beneficial effects?

Elements such as methylsulfonylmethane must be studied very carefully, because the properties it retains can be useful for the treatment of various problems. Let’s analyze them more carefully, focusing on those that science has identified as proven.

Methylsulfonylmethane for the intestine

Speaking of gut health and MSM, we cannot fail to underline how much research has been able to identify benefits in the gut . One of these relates to the treatment of the so-called “leaky bowel syndrome” . With the use of MSM it was possible to find a greater capacity of the intestinal cells to absorb liquids and food .

Chondroprotector properties

This factor should not come as a surprise, because methylsulfonylmethane, just like glucosamine and chondroitin, has chondroprotective properties. Integrating MSM means promoting the reduction of joint pain and inflammation . A decisive contribution in the recovery of normal mobility, by repairing damage to the cartilage .

Speeding up the healing process

While not directly involved in wound healing, the skin action of MSM is indirectly beneficial for wound healing . In this regard, the considerations previously made on sulfur are indispensable. Another usefulness of this element is to participate directly in the production of collagen .

Collagen, in fact, plays an indispensable role in maintaining the elasticity of the tissues. An effect that improves the reactivity of the same in the healing processes and also the ability to resist tearing.

MSM as a useful anti-inflammatory

Of all the known benefits of methylsulfonylmethane, it is certainly the anti-inflammatory one that guarantees the most interesting results. The action of this molecule is decisive in the fight against free radicals . This means evidently slowing down the aging and wear of the tissues .

At the cellular level, the action of MSM also coincides with an evident ability of the molecule to limit the loss of the latter.

We now come to deepen what are the most important information regarding the dosage of methylsulfonylmethane.

Methylsulfonylmethane dosage

The discourse relating to the dosage of MSM does not include a rather large literature and generally there is no tendency to provide a stringent prescription on this topic. The researches that have led to convincing results have considered doses of 500 mg of methylsulfonylmethane 2 times a day up to a maximum of 3 times .

No particular problems were highlighted in subjects who took 1 to 3 grams per day in specific cases , such as in subjects who were treating osteoarthritis . More precise information, on the other hand, can be shared regarding the timing of the hiring. It is advisable to take methylsulfonylmethane before or after meals , while it is highly not recommended to take methylsulfonylmethane before going to sleep .

Once basic information about the dosage has been underlined, it is essential to know more thoroughly the possible side effects and, therefore, the contraindications.

Methylsulfonylmethane: side effects and contraindications

Just like the beneficial effects, even those that can be considered as side effects and contraindications are still being studied. In these paragraphs we will enter the most important considerations relating to contraindications and side effects, also helping us with a summary scheme.

MSM side effects

An in-depth discussion on the side effects of methylsulfonylmethane should be done by analyzing a long series of studies that have shown very few results on its harmfulness .

The right dosage of the product, thanks to the expert opinion of a doctor, makes this absolutely safe and it is difficult to find obvious side effects outside of:

  • Diarrhea;
  • Nausea;
  • Intestinal disorders.

This type of disorders emerged in subjects with long-term administration. That is, in people who have taken the product for more than 3 consecutive months.

Methylsulfonylmethane: risks

It is essential to argue that it is essential to consult with a specialist before taking this product under certain conditions. In general, MSM is not recommended for pregnant or breastfeeding women .

Respecting the dosage and the instructions of your doctor, there are no particular risks to report even with regard to long-term intake.

After having explored such a broad topic, it is time to collect the most important issues relating to methylsulfonylmethane and insert them in the final part of our resource as a FAQ. Here are the most important.

FAQ on methylsulfonylmethane

Starting from the simplest ones, relating to the usefulness of this molecule, to the less emphasized curiosities about a product capable of helping to improve numerous pathological conditions.

What is methylsulfonylmethane used for?

This molecule is essential for a balanced nourishment of cartilage and bone tissue . It contributes to the nourishment of these tissues, but also to their regeneration. Through a process of synthesis it is also able to facilitate the production of collagen .

What foods contain MSM?

The main reference is to the sulfur molecule which is present in methylsulfonylmethane which, however, alone cannot satisfy the processes listed in the previous question. A complete supplement also includes elements such as glucosamine and chondroitin. In any case, there are many foods that have a fair amount of sulfur, such as milk, fruit, vegetables, coffee, meat and fish .

When and how to take methylsulfonylmethane?

Precisely the habit of recommending the intake of this molecule together with others in the form of a supplement, does not allow us to have an absolutely precise picture on the dosage. Here we make an example relating to a problem such as arthrosis . In these cases it is advisable to take 1 to 3 grams of MSM per day . Intake should preferably take place before or after meals .

Is it true that methylsulfonylmethane helps hair growth?

A lot of scientific confirmation is still needed. Some studies have shown some encouraging results . Using an MSM-based supplement can help improve the health of many tissues.

There are really many possibilities of using methylsulfonylmethane and the problems that this can cure in different body areas are really many. Study the right way to take it by considering our suggestions about it.

Contact our experts

Call us


Send an e-mail

Other articles you may be interested in



Loofah is a plant belonging to the Cucurbitaceae family, also known as “sponge zucchini.” In fact, the popularity of this plant comes from the zucchini

Read everything "
Fiocchi d'avena


Dyslipidemia is a condition characterized by the presence of abnormal levels of blood lipids, such as cholesterol and triglycerides. Diagnosis of this condition is very

Read everything "


Loofah is a plant belonging to the Cucurbitaceae family, also known as “sponge zucchini.” In fact, the popularity of this plant comes from the zucchini

Read everything "